原著論文（*：corresponding author）
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2024年
Wu, Z., Omura, I., Saito, A., Imaizumi, K. & Kamikawa, Y.* VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma. Nucleus, online ahead of print.
Uchida, T.*, Umetsu, S., Sasaki, M., Yoshimura, H., Omura, I. & Ishimori, K. A dye-decolorizing peroxidase from Vibrio Cholerae can demetallate heme. Journal of Inorganic Biochemistry, online ahead of print.
Ito, T., Saito, A.*, Kamikawa, Y., Nakazawa, N. & Imaizumi, K.* AIbZIP/CREB3L4 promotes cell proliferation via the SKP2-p27 axis in luminal androgen receptor subtype triple negative breast cancer. Molecular Cancer Research, 22, 373-385, 2024.
Sue, N., Thai, L.M., Saito, A., Boyer, C.K., Fordham, A.M., Yan, C., Davenport, A., Tao, J., Bensellam, M., Cantley, J., Shi, Y., Stephens, S.B., Imaizumi, K. & Biden, T.J.* Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by coordinating insulin biosynthesis with secretory granule formation. Molecular Metabolism, 79, 101845, 2024.
2023年
Saito, A.*, Kamikawa, Y., Ito, T., Matsuhisa, K., Kaneko, M., Okamoto, T., Yoshimaru, T., Matsushita, Y., Katagiri, T. & Imaizumi, K.* p53-independent tumor suppression by cell cycle arrest via CREB/ATF transcription factor OASIS. Cell Reports, 42, 112479, 2023.
Kamikawa, Y.*, Wu, Z., Nakazawa, N., Ito, T., Saito, A. & Imaizumi, K.* Impact of cell cycle on repair of ruptured nuclear envelope and sensitivity to nuclear envelope stress in glioblastoma. Cell Death Discovery, 9, 233, 2023.
2022年
Omura, I., Ishimori, K. & Uchida, T.* Converting cytochrome c into a DyP-like metalloenzyme. Dalton Transactions, 51, 12641-12649, 2022.
2021年
Kamikawa, Y., Saito, A., Matsuhisa, K., Kaneko, M., Asada, R., Horikoshi, Y., Tashiro, S. & Imaizumi K.* OASIS/CREB3L1 is a factor that responds to nuclear envelope stress. Cell Death Discovery, 7, 152, 2021.
Uchida, T.*, Omura, I., Umetsu, S. & Ishimori, K. Radical transfer but not heme distal residues is essential for pH dependence of dye-decolorizing activity of peroxidase from Vibrio cholerae. Journal of Inorganic Biochemistry, 219, 111422, 2021.
2020年
Matsuhisa, K., Cai, L., Saito, A., Sakaue, F., Kamikawa, Y., Fujiwara, S., Asada, R., Kudo, Y. & Imaizumi, K.* Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells. Brain Research, 1749, 147139, 2020.
Matsuhisa, K., Saito, A., Cai, L., Kaneko, M., Okamoto, T., Sakaue, F., Asada, R., Urano, F., Yanagida, K., Okochi, M., Kudo, Y., Matsumoto, M., Nakayama, K. & Imaizumi, K.* Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis. FASEB Journal, 34, 865-880, 2020.（1st and 2nd authors have co-first authorship）
Okamoto, T., Wu, Y., Matsuhisa, K., Saito, A., Sakaue, F., Imaizumi, K. & Kaneko M.* Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its beta1 subunit. Biochemical and Biophysical Research Communications, 521, 1030-1035, 2020.
2019年
Osaki, Y., Matsuhisa, K., Che, W., Kaneko, M., Asada, R., Masaki, T., Imaizumi, K.* & Saito, A.* Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II. Biochemical and Biophysical Research Communications, 514, 217-223, 2019.
Wu, Y., Kimura, Y., Okamoto, T., Matsuhisa, K., Asada, R., Saito, A., Sakaue, F., Imaizumi, K. & Kaneko, M.* Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. Scientific Reports, 9, 20301, 2019.
Maeoka, Y., Okamoto, T., Wu, Y., Saito, A., Asada, R., Matsuhisa, K., Terao, M., Takada, S., Masaki, T., Imaizumi, K. & Kaneko M.* Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5. Biochemical and Biophysical Research Communications, 514, 436-442, 2019.
Maeoka, Y., Wu, Y., Okamoto, T., Kanemoto, S., Guo, X.P., Saito, A., Asada, R., Matsuhisa, K., Masaki, T., Imaizumi, K. & Kaneko M.* NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells. Journal of Biological Chemistry, 294, 101-115, 2019.
2018年
Osaki, Y., Saito, A.*, Kanemoto, S., Kaneko, M., Matsuhisa, K., Asada, R., Masaki, T., Orii, K., Fukao, T., Tomatsu, S. & Imaizumi, K.* Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II. Cell Death & Disease, 9, 808, 2018.
Saito, A.*, Cai, L., Matsuhisa, K., Ohtake, Y., Kaneko, M., Kanemoto, S., Asada, R. & Imaizumi, K.* Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma. Journal of Neurochemistry, 144, 35-49, 2018.
Ohtake, Y., Matsuhisa, K., Kaneko, M., Kanemoto, S., Asada, R., Imaizumi, K.* & Saito, A.* Axonal activation of the unfolded protein response promotes axonal regeneration following peripheral nerve injury. Neuroscience, 375, 34-48, 2018.
Wu, Y., Guo, X.P., Kanemoto, S., Maeoka, Y., Saito, A., Asada, R., Matsuhisa, K., Ohtake, Y., Imaizumi, K. & Kaneko, M.* Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183. PloS One, 13, e0190407, 2018.
2016年
Cui, X., Cui, M., Asada, R., Kanemoto, S., Saito, A., Matsuhisa, K., Kaneko, M. & Imaizumi, K.* The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression. Scientific Reports, 6, 37310, 2016.
Arima, Y., Shiraishi, H., Saito, A., Yoshimoto, K., Namera, A., Makita, R., Murata, K., Imaizumi, K. & Nagao, M.* The sarin-like organophosphorus agent bis(isopropyl methyl)phosphonate induces ER stress in human astrocytoma cells. Journal of Toxicological Sciences, 41, 617-625, 2016.
Kanemoto, S., Nitani, R., Murakami, T., Kaneko, M., Asada, R., Matsuhisa, K., Saito, A. & Imaizumi, K.* Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress. Biochemical and Biophysical Research Communications, 480, 166-172, 2016.
2015年
Iwamoto, H., Matsuhisa, K., Saito, A., Kanemoto, S., Asada, R., Hino, K., Takai, T., Cui, M., Cui, X., Kaneko, M., Arihiro, K., Sugiyama, K., Kurisu, K., Matsubara, A. & Imaizumi, K.* Promotion of cancer cell proliferation by cleaved and secreted luminal domains of ER stress transducer BBF2H7. PLoS One, 10, e0125982, 2015.
Okada, M., Ikegawa, S., Morioka, M., Yamashita, A., Saito, A., Sawai, H., Murotsuki, J., Ohashi, H., Okamoto, T., Nishimura, G., Imaizumi, K. & Tsumaki N.* Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells. Human Molecular Genetics, 24, 299-313, 2015.
2014年
Saito, A., Kanemoto, S., Zhang, Y., Asada, R., Hino, K. & Imaizumi, K.* Chondrocyte proliferation regulated by secreted luminal domain of ER stress transducer BBF2H7/CREB3L2. Molecular Cell, 53, 127-139, 2014.
Hino, K., Saito, A.*, Kido, M., Kanemoto, S., Asada, R., Takai, T., Cui, M., Cui, X. & Imaizumi, K.* Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the ER stress transducer BBF2H7/CREB3L2 in chondrocytes. Journal of Biological Chemistry, 289, 13810-13820, 2014.
Hino, K., Saito, A., Asada, R., Kanemoto, S. & Imaizumi, K.* Increased susceptibility to dextran sulfate sodium-induced colitis in the endoplasmic reticulum stress transducer OASIS deficient mice. PLoS One, 9, e88048, 2014.
2013年
Miyagi, H., Kanemoto, S., Saito, A., Asada, R., Iwamoto, H., Izumi, S., Kido, M., Gomi, F., Nishida, K., Kiuchi, Y. & Imaizumi K.* Transcriptional regulation of VEGFA by the endoplasmic reticulum stress transducer OASIS in ARPE-19 cells. PLoS One, 8, e55155, 2013.
2012年
Saito, A., Kanemoto, S., Kawasaki, N., Asada, R., Iwamoto, H., Oki, M., Miyagi, H., Izumi, S., Sanosaka, T., Nakashima, K. & Imaizumi, K.* Unfolded protein response activated by OASIS family transcription factors promotes astrocyte differentiation. Nature Communications, 3, 967, 2012.
Izumi, S.,Saito, A.*, Kanemoto, S., Kawasaki, N., Asada, R., Iwamoto, H., Oki, M., Miyagi, H., Ochi, M. & Imaizumi, K.* The endoplasmic reticulum stress transducer BBF2H7 suppresses apoptosis by activating the ATF5-MCL1 pathway in growth plate cartilage. Journal of Biological Chemistry, 287, 36190-36200, 2012.
Kawasaki, N., Asada, R., Saito, A., Kanemoto, S. & Imaizumi, K.* Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Scientific Reports, 2, 799, 2012.
Asada, R., Saito, A., Kawasaki, N., Kanemoto, S., Iwamoto, H., Oki, M., Miyagi, H., Izumi, S. & Imaizumi, K.* The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine. Journal of Biological Chemistry, 287, 8144-8153, 2012.
Kondo, S., Hino, S-I.,Saito, A., Kanemoto, S., Kawasaki, N., Asada, R., Izumi, S., Iwamoto, H., Oki, M., Miyagi, H., Kaneko, M., Nomura, Y., Urano, F. & Imaizumi K.* Activation of OASIS family, ER stress transducers, is dependent on its stabilization. Cell Death & Differentiation, 19, 1939-1949, 2012.
2011年
Saito, A., Ochiai, K., Kondo, S., Tsumagari, K., Murakami, T., Cavener, D.R. & Imaizumi K.* Endoplasmic reticulum stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. Journal of Biological Chemistry, 286, 4809-4818, 2011.
2010年
Sekiya, H., Murakami, T., Saito, A., Hino, S-I., Tsumagari, K., Ochiai, K. & Imaizumi, K.* Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice. Journal of Bone and Mineral Metabolism, 28, 384-394, 2010.
Hino, S-I., Kondo, S., Yoshinaga, K., Saito, A., Murakami, T., Kanemoto, S., Sekiya, H., Chihara, K., Aikawa, Y., Hara, H., Kudo, T., Sekimoto, T., Funamoto, T., Chosa, E. & Imaizumi, K.* Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis. Journal of Bone and Mineral Metabolism, 28, 131-138, 2010.
2009年
Murakami, T., Saito, A., Hino, S-I., Kondo, S., Kanemoto, S., Chihara, K., Sekiya, H., Tsumagari, K., Ochiai, K., Yoshinaga, K., Saitoh, M., Nishimura, R., Yoneda, T., Kou, I., Furuichi, T., Ikegawa, S., Ikawa, M., Okabe, M., Wanaka, A. & Imaizumi, K.* Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nature Cell Biology, 11, 1205-1211, 2009.
Saito, A., Hino, S-I., Murakami, T., Kanemoto, S., Kondo, S., Saitoh, M., Nishimura, R., Yoneda, T., Furuichi, T., Ikegawa, S., Ikawa, M., Okabe, M. & Imaizumi, K.* Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis. Nature Cell Biology, 11, 1197-1204, 2009.
Chihara, K., Saito, A., Murakami, T., Hino, S-I., Aoki, Y., Sekiya, H., Aikawa, Y., Wanaka, A. & Imaizumi, K.* Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice. Journal of Neurochemistry, 110, 956-965, 2009.（1st and 2nd authors have co-first authorship）
Inokuchi, Y., Nakajima, Y., Shimazawa, M., Kurita, T., Kubo, M., Saito, A., Sajiki, H., Kudo, T., Aihara, M., Imaizumi, K., Araie, M. & Hara, H.* Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Investigative Ophthalmology & Visual Science, 50, 334-344, 2009.
2008年
Hosoi, T., Saito, A., Kume, A., Okuma, Y., Nomura, Y. & Ozawa, K.* Vanadate inhibits endoplasmic reticulum stress responses. European Journal of Pharmacology, 594, 44-48, 2008.（1st and 2nd authors have co-first authorship）
2007年
Kondo, S., Saito, A., Hino, S-I., Murakami, T., Ogata, M., Kanemoto, S., Nara, S., Yamashita, A., Yoshinaga, K., Hara, H. & Imaizumi, K.* BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Molecular and Cellular Biology, 27, 1716-1729, 2007.
Murakami, T., Hino, S-I., Saito, A. & Imaizumi, K.* Endoplasmic reticulum stress response in dendrites of cultured primary neurons. Neuroscience, 146, 1-8, 2007.
Hino, S-I., Kondo, S., Sekiya, H., Saito, A., Kanemoto, S., Murakami, T., Chihara, K., Aoki, Y., Nakamori, M., Takahashi, M.P. & Imaizumi, K.* Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1. Human Molecular Genetics, 16, 2834-2843, 2007.
2006年
Ogata, M., Hino, S-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., Shiosaka, S., Hammarback, J.A., Urano, F. & Imaizumi, K.* Autophagy is activated for cell survival after endoplasmic reticulum stress. Molecular and Cellular Biology, 26, 9220-9231, 2006
Murakami, T., Kondo, S., Ogata, M., Kanemoto, S., Saito, A., Wanaka, A. & Imaizumi, K.* Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress. Journal of Neurochemistry, 96, 1090-1100, 2006.
2005年
Okumura, M., Kondo, S., Ogata, M., Kanemoto, S., Murakami, T., Yanagida, K., Saito, A. & Imaizumi, K.* Candidates for tumor-specific alternative splicing. Biochemical and Biophysical Research Communications, 334, 23-29, 2005.